The One-carbon Therapeutics team is proud and excited to share our latest paper published in
Nature Metabolism describing the detailed mode of action of our potent MTHFD1/2 inhibitor
TH9619 under development for difficult-to-treat cancers. It explains the inhibitor’s cancer specificity
and emphasises the importance of utilising correct human-like conditions and cancer models in drug
development. We show that cancer-specific formate overflow drives toxic folate trapping upon
inhibition of cytosolic MTHFD1, leading to cancer cell death.
One-carbon Therapeutics announces oversubscribed private placement financing of SEK 153 million (€13.9 million)
Solna, Sweden, December 1, 2025. One-carbon Therapeutics AB, a clinical-stage
