Detailed mode of action of the MTHFD1/2 inhibitor TH9619 now published in Nature Metabolism

The One-carbon Therapeutics team is proud and excited to share our latest paper published in
Nature Metabolism describing the detailed mode of action of our potent MTHFD1/2 inhibitor
TH9619 under development for difficult-to-treat cancers. It explains the inhibitor’s cancer specificity
and emphasises the importance of utilising correct human-like conditions and cancer models in drug
development. We show that cancer-specific formate overflow drives toxic folate trapping upon
inhibition of cytosolic MTHFD1, leading to cancer cell death.

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