Scientific References

Read more about our targets and our scientific approach.

April 2023

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

Alanna C. Green, Petra Marttila et al.
Nature Metabolism

July 2022

Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis

Qi Meng, Yun-Xin Lu et al.
Oncogene

May 2022

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

Thomas Helleday and Sean G Rudd
Molecular Oncology

April 2020

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?

Zhiyuan Zhu and Gilberto Ka Kit Leung, Scientific Reports

April 2020

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?

Zhiyuan Zhu and Gilberto Ka Kit Leung

February 2022

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina M. S. Gustafsson et al.
Nature Cancer

June 2019

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Sara Sdelci, André F Rendeiro et al.
Nature Genetics

February 2017

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Robert Gustafsson, Ann-Sofie Jemth et al.
Cancer Research

October 2015

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

Nina Gustafsson Sheppard, Lisa Jarl et al.
Scientific Reports

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